Pyridazino [4,5-b]-quinoline 5-oxide derivatives, their...

Details Pyridazino [4,5-b]-quinoline 5-oxide derivatives, their... Pyridazino [4,5-b]-quinoline 5-oxide derivatives, their...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/50 (2006.01) A61K 31/5025 (2006.01) C07D 491/147 (2006.01)

Patent

CA 2261923

Pyridyl-phtalazin diones having formula (I), wherein R1 and R2 are selected from the group consisting of hydrogen, halogen, and methoxy or wherein R1 and R2 together form methylenedioxy, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing an effective glycines antagonistic amount thereof, are useful in combatting neurological disorders associated with excitotoxicity and malfunctioning of glutamatergic neurotransmission in a living animal, including a human, in need thereof.

Diones de pyridylphtalazine possédant la formule (I): dans laquelle R1 et R2 sont sélectionnés dans le groupe constitué par hydrogène, halogène et méthoxy ou dans laquelle R1 et R2 constituent ensemble méthylènedioxy, ainsi que leurs sels acceptables sur le plan pharmaceutique et compositions pharmaceutiques contenant une quantité antagoniste efficace de glycineB, utiles pour lutter contre des troubles neurologiques associés à l'excitotoxicité et contre le dysfonctionnement de la neurotransmission glutamatergique chez l'animal, y compris l'homme.

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