A nutriceutical composition for the correction of impaired...

A - Human Necessities – 61 – K

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A61K 33/06 (2006.01) A61K 31/122 (2006.01) A61K 31/20 (2006.01) A61K 31/355 (2006.01) A61K 31/375 (2006.01) A61K 31/435 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2484691

By recognizing that impaired endothelium-dependent arterial vasomotor response, or "endothelial dysfunction", is the central manifestation of both established and pre-clinical atherosclerosis, a nutritional composition has been invented. The composition provides a novel mixture of ingredients each one of which having been chosen on the basis of its demonstrated ability to reverse endothelial dysfunction in individuals suffering from a disease of atherosclerosis or in individuals who are disease-free but carry at least one risk factor for atherosclerosis. The composition consists of pharmacological doses of folic acid, niacin, vitamin C, vitamin E, coenzyme Q, omega-3 polyunsaturated fatty acids, and magnesium salt. It is recognized that any individual who, unpredictably, may be refractory to one or more of the aforementioned agents will likely be responsive to the other agents and thereby receive benefit from the composition as a whole. Furthermore, individuals who are responsive to more than one agent, or all the agents, will enjoy particular benefit from the composition by virtue of the additive effects of the individual agents. Thus, by reversing endothelial dysfunction in at-risk, disease-free individuals, the earliest step of atherogenesis can be blocked and disease development can be prevented; and, by treating individuals afflicted with any one of the diseases of atherosclerosis - coronary artery disease, cerebrovascular disease or peripheral vascular disease - the chance of ischemic attacks can be reduced.

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