Mutant f. tularensis strain and uses thereof

Details Mutant f. tularensis strain and uses thereof Mutant f. tularensis strain and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 1/21 (2006.01) A61K 39/02 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2606673

A mutant strain of Francisella tularensis has attenuated virulence and has a mutation in the gene coding for a putative peroxynitrite resistance protein A (prpA) which prevents normal function of the protein. The mutant is useful as a vaccine against type A and B virulent strains of F. tularensis, and is produced by obtaining a virulent F. tularensis strain and mutating the gene, FTT0918, that codes for prpA.

L'invention concerne une souche mutante de Francisella tularensis à virulence atténuée dont le gène codant une protéine A de résistance de la peroxynitrite putative (prpA) empêchant le fonctionnement normal de la protéine à muter. Le mutant est utilisé comme vaccin contre les souches virulentes de type A et B de F. tularensis, et est obtenu au moyen d'une souche virulente de F. tularensis et de la mutation du gène FTT0918 codant prpA.

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