Syntheses and preparations of polymorphs of crystalline...

Details Syntheses and preparations of polymorphs of crystalline... Syntheses and preparations of polymorphs of crystalline...

C - Chemistry, Metallurgy

07

D

C07D 215/22 (2006.01) A61K 31/496 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2605128

The invention relates to polymorphic crystalline forms of aripiprazole, synthetic processes for their preparation and pharmaceutical compositions containing the same. These crystalline forms of aripiprazole can be readily milled and can be easily combined with various pharmaceutical adjuvants without effecting changes to their crystalline structure when, for example, pressed into tablet or capsule form.

L'invention concerne des formes cristallines polymorphes de l'aripiprazole, leurs procédés synthétiques de préparation et les compositions pharmaceutiques les contenant. Ces formes cristallines de l'aripiprazole peuvent être broyées et combinées facilement avec divers adjuvants pharmaceutiques sans que cela confère des modifications à leur structure cristalline lorsque, par exemple, elles sont pressées sous forme de comprimés ou sous forme de capsules.

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