Use of igf-i for the treatment of polycystic kidney disease...

A - Human Necessities – 61 – K

Patent

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A61K 38/30 (2006.01)

Patent

CA 2265972

In accordance with the present invention, there are provided methods for the treatment of polycystic kidney disease and related indications in mammals, employing IGF-I as the active agent. In accordance with another embodiment of the present invention, it has been discovered that IGF-I is an effective agent for the treatment of renal dysplasias and/or renal hypoplasias in mammals. In accordance with yet another embodiment of the present invention, it has been discovered that IGF-I is an effective agent for enhancing glomerular development in mammals. In accordance with still another embodiment of the present invention, it has been discovered that IGF-I is an effective agent for enhancing kidney development in mammals suffering from chronic organ injury. In accordance with a further embodiment of the present invention, it has been discovered that IGF-I is an effective agent for protecting subjects from the ongoing toxicity of treatment with steroid hormones. In accordance with a still further embodiment of the present invention, it has been discovered that IGF-I is an effective agent for maintaining substantially normal growth in neonates and pre-pubescent mammals exposed to high dose steroid hormone therapy.

L'invention porte sur des méthodes de traitement des polykystoses rénales et des troubles associés chez les mammifères, en utilisant l'IGF-I comme principe actif. Selon une première variante de la présente invention, il a été découvert que l'IGF-I est un agent efficace pour le traitement des dysplasies et/ou des hypoplasies rénales chez les mammifères. Selon une deuxième variante de la présente invention, il a été découvert que l'IGF-I est un agent efficace favorisant le développement glomérulaire chez les mammifères. Selon une troisième variante de la présente invention, il a été découvert que l'IGF-I est un agent efficace favorisant le développement des reins chez les mammifères souffrant de lésions organiques chroniques. Selon une quatrième variante de la présente invention, il a été découvert que l'IGF-I est un agent efficace permettant de protéger des sujets contre la toxicité accompagnant les traitements aux hormones stéroïdes. Selon une cinquième variante de la présente invention, il a été découvert que l'IGF-I est un agent efficace pour maintenir une croissance sensiblement normale chez les mammifères nouveaux-nés ou prépubères traités par de fortes doses d'hormones stéroïdes.

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