G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/567 (2006.01) C12N 5/073 (2010.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2492631
The present invention provides methods for identifying and/or enriching fetal cells from maternal blood, using as fetal cell markers the antibodies that the mother produces against paternally inherited fetal antigens. The fetal cell- maternal antibody complexes are identified and isolated using labelled agents that bind to the maternal antibodies. The present invention also provides fetal cells, isolated by use of said maternal antibodies, as a source of fetal DNA for prenatal genetic diagnosis of the fetus.
La présente invention concerne des procédés d'identification et/ou d'enrichissement de cellules foetales du sang maternel, utilisant comme marqueurs de cellules foetales les anticorps que la mère produit à l'encontre des antigènes foetaux hérités du père. Des complexes d'anticorps maternels/cellules foetales sont identifiés et isolés au moyen d'agents marqués se liant aux anticorps maternels. La présente invention concerne également des cellules foetales, isolées au moyen desdits anticorps maternels, tenant lieu de source d'ADN foetal en vue du diagnostic prénatal et génétique du foetus.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Genetic Technologies Limited
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