Methods and compositions for stimulating neurite growth

Details Methods and compositions for stimulating neurite growth Methods and compositions for stimulating neurite growth

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/33 (2006.01) A61K 31/40 (2006.01) A61K 31/401 (2006.01) A61K 31/4025 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/4525 (2006.01) A61K 31/4535 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/52 (2006.01) A61K 31/5377 (2006.01) A61K 38/18 (2006.01) C12N 5/00 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01)

Patent

CA 2222430

The present invention relates to methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compositions comprise a neurotrophic amount of a compound which binds to the FK-506 binding protein (FKBP) and a neurotrophic factor, such as nerve growth factor NGF. The methods comprise treating nerve cells with the above-described compositions or compositions comprising the FKBP binding compound without a neurotrophic factor. The methods of this invention can be used to promote repair of neuronal damage caused by disease or physical trauma.

Procédés et compositions pharmaceutiques permettant de stimuler la croissance des neurites dans les cellules nerveuses. Lesdites compositions comprennent une quantité neurotrophique d'un composé qui se lie à la protéine de liaison FK-506 (FKBP) et un facteur neurotrophique tel que le facteur de croissance du tissu nerveux (NGF). Lesdits procédés consistent à traiter les cellules nerveuses avec les compositions décrites ci-dessus ou avec des compositions comprenant le composé de liaison FK-506 et exemptes de facteur neurotrophique. Les procédés de la présente invention peuvent être utilisés pour promouvoir la réparation de lésions neuronales causées par une maladie ou un traumatisme physique.

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