Liquid formulation of metformin

Details Liquid formulation of metformin Liquid formulation of metformin

A - Human Necessities

61

K

A61K 31/155 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2416767

The present invention is directed to a liquid formulation of metformin or its pharmaceutically acceptable salts thereof. The liquid pharmaceutical composition comprises a therapeutically effective amount of metformin or its pharmaceutically acceptable salt, in a liquid carrier, which may also include a sweetener that does not increase the blood glucose level of a subject after ingestion thereof. In one embodiment, it may also include alkyl hydroxyethyl- cellulose, and/or a polyhydroxy alcohol. In another embodiment, the carrier may contain a sweetener, mineral acid, and bicarbonate salt maintained at a pH of 4.0 to 9Ø It is useful for treating hyperglycemia and diabetes.

La présente invention concerne une formulation liquide de metformine ou de ses sels acceptables du point de vue pharmaceutique. La composition pharmaceutique liquide comprend une quantité efficace du point de vue thérapeutique de metformine ou d'un de ses sels acceptable du point de vue pharmaceutique, dans un excipient liquide, qui peut également comprendre un édulcorant qui ne fait pas augmenter le taux de glucose sanguin du patient après ingestion de ladite composition. Dans un mode de réalisation, ladite composition peut également comprendre un alkyl hydroxyéthyl cellulose, et/ou un polyhydroxy alcool. Dans un autre mode de réalisation, l'excipient peut contenir un édulcorant, un acide minéral, et un sel de bicarbonate maintenu à un pH de 4,0 à 9,0. Ladite composition peut être utilisée pour traiter l'hyperglycémie et le diabète.

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