Acetohydroxamic acids

Details Acetohydroxamic acids Acetohydroxamic acids

C - Chemistry, Metallurgy

07

D

260/267.4, 260/5

C07D 235/16 (2006.01) C07C 57/72 (2006.01) C07C 275/28 (2006.01) C07C 275/30 (2006.01) C07D 223/22 (2006.01) C07D 233/72 (2006.01) C07D 233/74 (2006.01) C07D 233/76 (2006.01) C07D 279/22 (2006.01) C07D 295/15 (2006.01) C07D 317/56 (2006.01)

Patent

CA 1120928

ABSTRACT OF THE DISCLOSURE The invention provides new acetohydroxamic acid derivatives, having interesting properties on the central nervous system, of the formula: R1R2R3C-CO-NHOH, in which R2 and R3 are each hydrogen or C1-6 alkyl, and R1 is C1-6 alkyl Z1Z2N (where Z1 and Z2 are each phenyl, substituted phenyl, or cycloalkyl), substituted hydantoinyl, benzhydroxyl- carboxamido, Z3 CH2- (where Z3 = optionally substituted aryl), Z4-A- (where Z4 is optionally substituted phenyl or naphthyl, and A is -NH-, -N(C1-4 alkyl)-, N(C5-6 cycloalkyl) , -NHCO-, -N(C1-4 alkyl)CO-, -N(C5-6 cycloalkyl)CO-, -CONH-, -CON(C1-4 alkyl)-, -CON(C5-6 cycloalkyl)-, -NHC5NH-, -N(C5H6)CONH-, or -N(substituted phenyl)CONH-, optionally substituted benzimidazolyl, or an optionally substituted tricyclic radical, and their metal and acid addition salts.

274470

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