Combination of an hmg coa reductase inhibitor and other type...

Details Combination of an hmg coa reductase inhibitor and other type... Combination of an hmg coa reductase inhibitor and other type...

A - Human Necessities

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A61K 31/35 (2006.01) A61K 31/19 (2006.01) A61K 31/34 (2006.01) A61K 31/365 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/455 (2006.01) A61K 31/66 (2006.01)

Patent

CA 2003478

Abstract COMBINATION OF AN HMG CoA REDUCTASE INHIBITOR AND OTHER TYPE OF SERUM CHOLESTEROL REDUCING AGENT AND METHOD FOR LOWERING SERUM CHOLESTEROL USING SUCH COMBINATION A pharmaceutical combination is provided which includes an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, such as lovastatin, pravastatin or velostatin, and a pharmaceutical which reduces serum cholesterol and/or inhibits cholesterol biosynthesis by a mechanism other than inhibiting production of the enzyme HMG CoA reductase, namely, probucol or niacin. A method for reducing serum cholesterol or inhibiting formation of or treating atherosclerosis using the above combination is also provided.

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