C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/16 (2006.01) A61K 31/407 (2006.01) A61P 31/12 (2006.01) C07D 515/16 (2006.01)
Patent
CA 2693537
A class of macrocyclic compounds of formula (I), wherein R7,A,Ar, B,D, F, M, Q1, Q2, W, X, Y and Z are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Alsoprovided are processes for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection.
L'invention porte sur une classe de composés macrocycliques représentés par la formule (I), dans laquelle R7, A, Ar, B, D, F, M, Q1, Q2, W, X, Y et Z sont tels que définis présentement, qui sont utiles comme inhibiteurs de protéases virales, en particulier la protéase NS3 du virus de l'hépatite C (VHC). L'invention porte également sur des procédés pour la synthèse et l'utilisation de tels composés macrocycliques pour le traitement ou la prévention de l'infection par le VHC.
Conte Immacolata
Ferreira Maria Del Rosario Rico
Habermann Joerg
Mackay Angela Claire
Narjes Frank
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
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