Gapped 2' modified oligonucleotides

Details Gapped 2' modified oligonucleotides Gapped 2' modified oligonucleotides

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 19/04 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C07K 2/00 (2006.01) C07K 9/00 (2006.01) C07K 14/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2126691

Oligonucleotides and other macromolecules are provided that have increased nuclease resistance, substituent groups for in- creasing binding affinity to complementary strand, and subsequences of 2'- deoxy-erythro-pentofuranosyl nucleotides that acti- vate RNase H enzyme. Such oligonucleotides and macromolecules are useful for diagnostics and other research purposes, for modulating protein in organisms; and for the diagnosis, detection and treatment of other conditions susceptible to antisense ther- apeutics.

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