Use of na,k-atpase a-and b-subunits in bladder cancer...

Details Use of na,k-atpase a-and b-subunits in bladder cancer... Use of na,k-atpase a-and b-subunits in bladder cancer...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/34 (2006.01) C12Q 1/42 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2480665

Methods are provided for determining the malignancy of cells in a bladder carcinoma sample. Expression patterns of Na,K-ATPase .alpha. and .beta. subunits are shown to be associated with recurrence risk in these cancers. Detection of Na,K-ATPase .alpha. and .beta. subunits expression in bladder carcinomas provides a useful diagnostic for predicting patient prognosis and probability of drug effectiveness. Na,K-ATPase .alpha. and .beta. subunits provide a target for drug screening.

L'invention concerne des procédés visant à déterminer la malignité de cellules dans un échantillon de carcinome de la vessie. Il a pu être établi que les motifs d'expression des sous-unités .alpha. et .beta. de la Na,K-ATPase sont associés à un risque de récurrence dans ces cancers. La détection des sous-unités .alpha. et .beta. de la Na,K-ATPase dans les carcinomes de la vessie fournit un diagnostic utile pour formuler un pronostic du patient et évaluer la probabilité d'efficacité d'un médicament. Les sous-unités .alpha. et .beta. de la Na,K-ATPase constituent une cible pour le criblage de médicaments.

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