C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/30 (2006.01) A61K 39/005 (2006.01) C07K 14/44 (2006.01) C07K 19/00 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2237299
Compounds and methods are provided for diagnosing Trypanosoma cruzi infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of T. cruzi antigens. The compounds are useful in a variety of immunoassays for detecting T. cruzi infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for inducing protective immunity against Chagas' disease in individuals exposed to T. cruzi.
Composés et procédés de diagnostic d'infections par Trypanosoma cruzi. Les composés décrits sont des polypeptides, ou des anticorps contre ceux-ci, contenant un ou plusieurs épitopes d'antigènes de T. cruzi. Les composés sont utiles dans divers immunotitrages de détection d'infection par T. cruzi. Les composés polypeptiques sont également utiles dans des vaccins et des compositions pharmaceutiques destinés à conférer une immunité protectrice contre la maladie de Chagas chez des individus exposés à T. cruzi.
Houghton Raymond L.
Lodes Michael J.
Reed Steven G.
Skeiky Yasir A. W.
Corixa Corporation
Gowling Lafleur Henderson Llp
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