Monoclonal antibody to lymphocyte-associated cell surface...

Details Monoclonal antibody to lymphocyte-associated cell surface... Monoclonal antibody to lymphocyte-associated cell surface...

C - Chemistry, Metallurgy

12

N

C12N 5/12 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 5/18 (2006.01) C12P 21/08 (2006.01) G01N 33/532 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2336561

A hybridoma cell line produced by the fusion of NS-1 myeloma cells with spleen cells obtained from mice immunized with Leukocyte Adhesion Molecule-1 (LAM-1) cDNA transfected cells. The cell line produces a monoclonal antibody reactive with human, monkey, cow, rabbit, sheep, dog, cat, pig and goat LAM-1. The monoclonal antibody produced by the cell line, anti-LAM1-3, may be clinically useful in blocking leukocyte entry into sites of inflammation or tissue injury.

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