C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/44 (2006.01) C12N 9/14 (2006.01) C12N 9/16 (2006.01) C12Q 1/00 (2006.01)
Patent
CA 2421938
The present invention relates to novel methods of signal transduction in cells. In particular, the invention relates to signal transduction via a class of enzymes known as phosphodiesterase enzymes or PDEs. The invention also relates to a class of signaling molecules known as G-coupled protein receptors (GCPRs) and G-proteins. The invention provides novel methods to screen for and identify G-proteins and other compounds which modulate signaling by these two classes of proteins. In particular, the relates to novel assays which identify compounds that modulate (e.g., enhance or inhibit) binding between a PDE polypeptide and an effector activation domain of a G-protein.
La présente invention concerne des procédés de transduction de signal dans des cellules. En particulier, l'invention a pour objet la transduction de signal par l'intermédiaire d'une catégorie d'enzymes connues sous le nom de phosphodiestérases ou PDE. Cette invention concerne également une catégorie de molécules de signalisation connues sous le nom de récepteurs à protéines à couplage G (GCPR) et protéines G. L'invention a pour objet des procédés permettant le criblage et l'identification de protéines G et autres composés qui modulent la signalisation par ces deux catégories de protéines. En particulier, l'invention concerne des essais permettant d'identifier des composés qui modulent (par ex. augmentent ou inhibent) la liaison entre un polypeptide PDE et un domaine d'activation effecteur d'une protéine G.
Beavo Joseph
Margolskee Robert
Moffat & Co.
Mount Sinai School Of Medicine
University Of Washington
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