A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4184 (2006.01) A61P 31/14 (2006.01)
Patent
CA 2723086
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, Pichinde, and LCMV), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever and Crimean-Congo hemorrhagic fever).
La présente invention concerne des composés, des procédés et des compositions pharmaceutiques destinés au traitement d'infections virales, par l'administration de certains nouveaux composés en quantités thérapeutiquement efficaces. La présente invention concerne également des procédés de préparation des composés et des procédés d'utilisation des composés, ainsi que des compositions pharmaceutiques les contenant. La présente invention concerne notamment le traitement et la prophylaxie d'infections virales telles que celles causées par les virus des fièvres hémorragiques, c'est-à-dire, comprenant de manière non restrictive, les Arenaviridae (les virus Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, Pichinde, et le LCMV), les Filoviridae (les virus d'Ebola et de Marburg), les Flaviviridae (les virus de la fièvre jaune, le virus de la fièvre hémorragique d'Omsk et le virus de la maladie de la forêt de Kyasanur), et les Bunyaviridae (virus de la fièvre de la vallée du Rift et virus de la fièvre hémorragique de Crimée-Congo).
Amberg Sean M.
Bolken Tove C.
Dai Dongcheng
Hruby Dennis E.
Larson Ryan A.
Mccarthy Tetrault Llp
Siga Technologies Inc.
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