Methods and compositions for immunomodulation

Details Methods and compositions for immunomodulation Methods and compositions for immunomodulation

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2268340

The instant invention discloses the unexpected result that two anti-4-1BB monoclonal antibodies can inhibit both primary and secondary humoral responses to at least T-cell dependent antigens in vivo. Such antibodies provide a novel approach to immunosuppression and cancer therapy in vivo.

L'invention concerne le résultat inattendu représenté par le fait que deux anticorps monoclonaux anti-4-1BB peuvent inhiber in vivo aussi bien la réponse humorale primaire que la réponse humorale secondaire à au moins des antigènes dépendants des cellules T. Ces anticorps permettent une nouvelle approche de l'immunosuppression et du traitement du cancer in vivo.

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