Phosphorus-containing hmg-coa reductase inhibitors, new...

Details Phosphorus-containing hmg-coa reductase inhibitors, new... Phosphorus-containing hmg-coa reductase inhibitors, new...

C - Chemistry, Metallurgy

07

F

167/231, 260/271

C07F 9/547 (2006.01) A61K 31/675 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2036407

HX29 Abstract PHOSPHORUS-CONTAINING HMG-CoA REDUCTASE INHIBITORS, NEW INTERMEDIATES AND METHOD Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholester- olemic agents are provided which have the structure Image including salts thereof, wherein R is OH, or lower alkoxy; Rx is H or alkyl; X is -(CH2)a- (where a is 1, 2 or 3), -CH=CH-, or -C?C-. New intermediates used in preparing the above compounds, pharmaceutical compositions containing such compounds and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.

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