Modified oligonucleotides having improved anti-influenza...

Details Modified oligonucleotides having improved anti-influenza... Modified oligonucleotides having improved anti-influenza...

C - Chemistry, Metallurgy

12

N

C12N 15/44 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) C12N 15/54 (2006.01)

Patent

CA 2159350

The invention provides anti-influenza modified oligonucleotides that have greater efficacy in inhibiting influenza replication or propagation than previously described oligonucleotides. The greater efficacy arises from structural features such as chimeric or hybrid backbones, nuclease resistance-conferring terminal capping structures and/or self-complementary regions.

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