Methods for the detection of nitric oxide in fluid media

Details Methods for the detection of nitric oxide in fluid media Methods for the detection of nitric oxide in fluid media

G - Physics

01

N

G01N 30/96 (2006.01) G01N 1/22 (2006.01) G01N 1/40 (2006.01) G01N 24/00 (2006.01) G01N 33/00 (2006.01) G01N 33/487 (2006.01)

Patent

CA 2271195

In accordance with the present invention, non-invasive methods have been developed for the measurement of NO levels in a variety of fluid media, e.g., in mammalian fluids. The present invention embraces the use of a semi- permeable membrane bag containing a nitric oxide reacting substance to trap NO diffusing in to the bag. The permeability of selected semi-permeable membranes to nitric oxide, but not to nitrate/nitrite, makes is possible for the semi- permeable membranes bags employed in the practice of the present invention to selectively collect NO, even in the presence of potentially competing species such as nitrate and nitrite. The simple, easy and non-invasive methods of the invention for the measurement of NO levels in fluid media will find a variety of uses, e.g., for diagnosis and monitoring of NO overproduction or underproduction that has been associated with many inflammatory and infectious diseases.

Selon la présente invention, des méthodes non invasives ont été mises au point pour mesurer les taux de NO dans divers milieux fluides, par exemple dans les fluides des mammifères. La présente invention concerne l'utilisation d'un sac à membrane semi-perméable contenant une substance qui réagit au monoxyde d'azote, de façon à piéger le NO diffusant à l'intérieur du sac. La perméabilité des membranes choisies, semi-perméables au monoxyde d'azote mais pas aux nitrates/nitrites, permet aux sacs employés pour la mise en oeuvre de la présente invention de prélever sélectivement le NO, même en présence d'espèces potentiellement concurrentes telles que les nitrates et les nitrites. Les méthodes simples, faciles et non invasives de l'invention, permettant de mesurer les taux de NO dans des milieux fluides, trouveront une grande variété d'utilisations, par exemple pour le diagnostic et la surveillance de la surproduction ou de la sous-production de NO associée à de nombreuses maladies inflammatoires et infectieuses.

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