Use of compounds in a dry powder inhaler

Details Use of compounds in a dry powder inhaler Use of compounds in a dry powder inhaler

A - Human Necessities

61

K

A61K 31/437 (2006.01) A61K 9/14 (2006.01) A61K 9/72 (2006.01) A61K 31/46 (2006.01) A61K 47/26 (2006.01) A61M 13/00 (2006.01) A61M 15/00 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 43/00 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2457717

The present invention relates to an inhaled formulation comprising a compound selected from a particular class of 5,6-dihydro-9H-pyrazolo[3,4-c]-1,2,4- triazolo[4,3-a]pyridines which is capable of delivering the compound as fine, solid particles to the lung and the use of such a formulation in the treatment of certain diseases such as respiratory diseases. By the use of such formulations, it is possible to eliminate the unwanted cough response associated with the use of these compounds in solution metered dose inhalers, which response can prevent the administration of a therapeutically effective dose and, in the long term, undermine patient compliance.

La présente invention concerne une préparation à inhaler qui comprend un composé choisi dans une classe particulière de 5,6-dihydro-9<I>H</I>-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-a]pyridines. Selon cette invention, le composé peut être distribué aux poumons sous forme de fines particules solides. Cette préparation convient au traitement de certaines maladies telles que les maladies respiratoires. L'utilisation de cette préparation permet d'éliminer la réponse de toux indésirable qui est associée à l'utilisation de ces composés dans des inhalateurs-doseurs à solution, sachant que cette réponse peut empêcher l'administration d'une dose efficace pour le traitement et, à long terme, démotiver le patient à respecter le traitement.

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