Novel receptors for $i(helicobacter pylori) and use thereof

Details Novel receptors for $i(helicobacter pylori) and use thereof Novel receptors for $i(helicobacter pylori) and use thereof

C - Chemistry, Metallurgy

07

H

C07H 13/04 (2006.01) A61K 31/702 (2006.01) A61K 31/715 (2006.01) A61K 39/106 (2006.01) A61K 47/48 (2006.01) A61P 1/04 (2006.01) A61P 31/04 (2006.01) C07H 3/06 (2006.01) C07H 13/06 (2006.01) C07H 15/00 (2006.01) C07H 15/06 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2434350

The present invention describes a substance or a receptor comprising Helicobacter pylori binding oligosaccharide sequence [Gal(A)q(NAc)r/Glc(A)q(NAc)r.alpha.3/.beta.3]s[Gal.beta.4GlcNAc.beta.3]tGal.bet a.4Glc(NAc)u wherein q, r, s, t, and u are each independently 0 or 1, and the use thereof in, e.g., pharmaceutical and nutritional compositions for the treatment of conditions due to the presence of Helicobacter pylori. The invention is also directed to the use of the receptor for diagnostics of Helicobacter pylori.

La présente invention concerne une substance ou un récepteur comprenant une séquence oligosaccharide se liant à Helicobacter pylori, et représentée par la formule suivante: [Gal(A)¿q?(NAc)¿r?/Glc(A)¿q?(NAc)¿r?.alpha.3/.beta.3]¿s?[Gal.beta.4GlcNAc.beta.3]¿t?Gal.beta.4Glc(NAc)¿u?. Dans cette formule, q, r, s, t, et u valent chacun indépendamment 0 ou 1. L'invention concerne également son utilisation notamment dans des compositions pharmaceutiques et nutritives pour le traitement d'états imputables à la présence deHelicobacter pylori. L'invention concerne enfin l'utilisation du récepteur pour un diagnostic de Helicobacter pylori.

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