Dolastatin-15 derivatives in combination with taxanes

Details Dolastatin-15 derivatives in combination with taxanes Dolastatin-15 derivatives in combination with taxanes

A - Human Necessities

61

K

A61K 38/08 (2006.01) A61K 31/337 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2282720

The present invention provides compositions and methods for the treatment of cancer in a subject wherein compounds of Formula (I) as defined herein in combination with paclitaxel, taxotere or modified taxane or taxoid analogs provide enhanced anticancer effects over the effects achieved with the individual compounds.

La présente invention concerne des compositions et des procédés pour traiter le cancer chez un sujet, chez lequel des composés de la formule I sont définis en association avec du paclitaxel, du taxotere ou du taxane modifié ou des analogues de taxoïde. Ces composés améliorent l'effet anti-cancéreux par rapport aux effets obtenus lors de leur utilisation sans association.

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