Immunogenic streptococcus proteins

G - Physics – 01 – N

Patent

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G01N 33/569 (2006.01) A61K 39/09 (2006.01)

Patent

CA 2695721

The invention provides means and methods for identifying a Streptococcus protein which is capable of eliciting an immune response against at least two Streptococcus strains and/or serotypes. The invention further discloses immunogenic compositions capable of eliciting an immune response against Streptococcus uberis comprising at least two recombinant and/or isolated proteins derived from Streptococcus uberis, and/or an immunogenic part or analogue or derivative of either or both of said proteins. The invention further discloses nucleic acid molecules encoding said proteins or immunogenic parts thereof, host cells and recombinant carriers comprising such nucleic acid molecule, and vaccines and diagnostic tests based on said proteins and nucleic acids.

L'invention concerne des moyens et des procédés permettant d'identifier une protéine de streptocoque qui est capable de provoquer une réponse immunitaire contre aux moins deux souches et/ou sérotypes de streptocoque. L'invention concerne en outre des compositions immunogènes capables de provoquer une réponse immunitaire contre Streptococcus uberis comprenant au moins deux protéines recombinantes et/ou isolées dérivées de Streptococcus uberis, et/ou une partie ou un analogue ou un dérivé immunogène de l'une ou l'autre ou des deux dites protéines. L'invention concerne en outre des molécules d'acides nucléiques codant lesdites protéines ou parties immunogènes de celles-ci, des cellules hôtes et des véhicules recombinants comprenant cette molécule d'acide nucléique, et des vaccins et des tests de diagnostic basés sur lesdits acides nucléiques et protéines.

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