Modified human growth hormone

Details Modified human growth hormone Modified human growth hormone

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/27 (2006.01) C07K 7/04 (2006.01) C07K 14/61 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) G01N 33/74 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2459138

The invention relates to the modification of human growth hormone (high) to result in human growth hormone proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in-vivo. The invention relates, furthermore, to T-cell epitome sequences deriving from high, which are immunogenic.

Cette invention concerne une modification de l'hormone de croissance humaine (hch) permettant d'obtenir des protéines de l'hormone de croissance humaine qui sont sensiblement non immunogènes ou moins immunogènes que tout homologue non modifié utilisé <i>in-vivo</i>. De plus, l'invention concerne des séquences épitopes de lymphocytes T tirés de hch, qui sont immunogènes.

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