Glycosylated polypeptides produced in yeast mutants and...

Details Glycosylated polypeptides produced in yeast mutants and... Glycosylated polypeptides produced in yeast mutants and...

C - Chemistry, Metallurgy

12

N

C12N 1/19 (2006.01) A61K 36/06 (2006.01) A61K 39/21 (2006.01) A61P 31/18 (2006.01) A61P 37/04 (2006.01) C07K 16/10 (2006.01) C12N 1/14 (2006.01) C12P 21/00 (2006.01) C07K 14/16 (2006.01)

Patent

CA 2623197

The invention provides various high mannose glycosylated polypeptides that are useful in a vaccine formulations. The invention also provides methods for making such glycosylated polypeptides and its uses in eliciting HIV- neutralizing antibodies.

L'invention concerne divers polypeptides glycosylés à teneur élevée en mannose utilisés dans des formulations de vaccin. L'invention concerne également des méthodes de fabrication desdits polypeptides glycosylés et leurs utilisations dans l'activation d'anticorps de neutralisation du VIH.

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