Multi-channel capillary electrophoresis device and method

G - Physics – 01 – N

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G01N 27/453 (2006.01) G01N 27/447 (2006.01)

Patent

CA 2445546

Embodiments of a device and method are described which provide for control over the distortion of a sample zone upon exiting an electrophoresis separation channel. According to the teachings herein (i) the downstream regions of the channels (14), near the outlet ends, and/or (ii) the detection chamber (50), is/are configured so that distortion of one or more sample zones passing from the channels into and across the detection chamber can be controlled (e.g., reduced) in a fashion affording enhanced detectability. In certain embodiments, the lumens along the end regions of the separation channels progressively expand.

L'invention concerne les modes de réalisation d'un dispositif et d'un procédé qui permettent de contrôler la distorsion d'une zone d'échantillonnage lorsqu'elle sort d'un canal de séparation par électrophorèse. Selon le descriptif, (i) les régions aval des canaux (14), situées à proximité des extrémités d'évacuation, et/ou (ii) la chambre de détection (50) sont conçus de façon que la distorsion d'une ou de plusieurs zone d'échantillonnage passant des canaux à la zone de détection en traversant cette dernière puissent être contrôlée (c'est-à-dire réduite) de façon à améliorer sa détectabilité. Dans certains modes de réalisation, les lumières qui s'étendent le long des régions d'extrémité des canaux de séparation se dilatent progressivement.

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