C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) B01D 15/08 (2006.01) B01D 15/32 (2006.01) B01D 15/36 (2006.01) B01J 20/26 (2006.01) B01J 20/28 (2006.01) G01N 30/52 (2006.01) G01N 30/88 (2006.01)
Patent
CA 2344051
The present invention provides monolithic polymer matrices for the separation of bio-organic molecules by liquid chromatography. In one embodiment, the matrix is formed from a polymerization mixture including (i) a hydrophobic monomer, (ii) a crosslinking agent, and (iii) a porogenic solvent or mixture of porogenic components. The monolithic matrices of the invention are particularly useful for resolving polynucleotides (e.g., DNA and/or RNA) in samples by way of reversed-phase ion-pairing chromatography.
La présente invention se rapporte à des matrices polymères monolithiques qui permettent la séparation de molécules bio-organiques par chromatographie en phase liquide. Dans une réalisation, la matrice est formée d'un mélange pour polymérisation comportant (i) un monomère hydrophobe, (ii) un agent de réticulation et (iii) un solvant porogène ou un mélange de composants porogènes. Les matrices monolithiques de cette invention sont particulièrement utiles pour séparer des polynucléotides (par exemple, ADN et/ou ARN) dans des échantillons au moyen d'une chromatographie par formation de paires d'ions sur supports non polaires.
Agilent Technologies Inc.
R. William Wray & Associates
Varian Inc.
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