Viscous agent for ophthalmic use

Details Viscous agent for ophthalmic use Viscous agent for ophthalmic use

A - Human Necessities

61

K

A61K 47/36 (2006.01) A61K 9/08 (2006.01) A61K 47/38 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2567418

It is intended to provide eye-drops which have a relatively low viscosity before the instillation but are thickened on the eyeball surface at the instillation. Eye-drops containing a thickener for ophthalmic use, which comprises a combination of hydroxyethylcellulose with dextran, exhibit a specific and synergistic thickening effect in the coexistence of mucin. Upon contact with mucin in the lacrimal layer at the instillation, therefore, the above eye-drops are thickened on the eyeball surface to thereby sustain the desired drug effect and refreshing feel.

On cherche à fournir un collyre de relativement faible viscosité avant l~instillation mais qui s~épaissit sur la surface du globe oculaire lors de l~instillation. Le collyre contient un épaississant à usage ophtalmique, composé d'une combinaison d~ hydroxyéthylcellulose et de dextran, a un effet épaississant synergétique et spécifique au contact de la mucine. Lors de l~instillation, le contact de la mucine dans la couche lacrymale entraîne donc l~épaississement du collyre sur la surface du globe oculaire, ayant ainsi pour résultat l~effet médical souhaité et une sensation rafraîchissante.

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