C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) C07K 14/16 (2006.01) C07K 14/18 (2006.01) C12N 5/10 (2006.01) C12N 15/48 (2006.01) C12N 15/51 (2006.01) C12N 15/86 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2268737
A replication-competent recombinant Sabin type 1 poliovirus vector containing a sequence coding for multiple cloning site and 3C-protease cleavage site is provided. This vector makes it easy to introduce various vaccine genes from infectious viruses to the Sabin 1 poliovirus, and facilitates to produce chimeric Sabin 1 polioviruses that are expected to be powerful oral mucosal vaccines against several infectious viral diseases.
L'invention concerne un vecteur recombiné de poliovirus 1 du type Sabin, à capacité de réplication, contenant une séquence codant pour un site de clonage multiple et un site de coupure multiple de protéase 3C. Ce vecteur facilite l'introduction de divers gènes vaccinaux de virus infectieux, dans le poliovirus du type 1 Sabin, et facilite la production de poliovirus chimères du type 1 Sabin, qui sont des vaccins buccaux destinés à être administrés à travers la muqueuse, et dirigés contre les maladies virales infectieuses graves.
Bae Yong Soo
Jung Hye Rhan
Altwell Biotech. Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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