Compositions and methods for increasing the stability of...

Details Compositions and methods for increasing the stability of... Compositions and methods for increasing the stability of...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 47/00 (2006.01) A61K 47/10 (2006.01) A61K 47/18 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2607663

The invention encompasses pharmaceutical compositions comprising an antibody and methods of formulating antibodies. The heavy and/or a light chain variable region of the antibody may have certain characteristics. In some embodiments, the antibody may comprise an N-glycan site in a heavy and/or light chain variable region. The compositions may comprise a buffering agent and, optionally, a sugar and/or a salt.

L'invention concerne des compositions pharmaceutiques comprenant un anticorps et des procédés de formulation de l'anticorps. La région variable de chaîne lourde et/ou légère de l'anticorps peut posséder certaines caractéristiques. Dans quelques modes de réalisation, l'anticorps peut comprendre un site N-glycane dans une région variable de chaîne lourde et/ou légère. Les compositions peuvent comprendre un tampon et éventuellement un sucre et/ou un sel.

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