A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 9/127 (2006.01) A61K 47/42 (2006.01) A61P 37/04 (2006.01)
Patent
CA 2686840
Disclosed is a liposome which includes an antigenic substance therein and has, on its surface, a peptide containing several contiguous arginine residues. The liposome enables an antigen-presenting cell to achieve the selective antigen presentation through a MHC class-I molecule, and can induce a cell-mediated immunity specifically. The liposome can also induce the antigen presentation by a matured dendritic cell.
La présente invention concerne un liposome qui comprend une substance antigénique incorporée et qui comporte, sur sa surface, un peptide contenant plusieurs résidus arginine contigus. Le liposome permet à une cellule présentatrice d'antigène d'assurer la présentation d'antigène sélective au moyen d'une molécule de classe I MHC et peut induire spécifiquement une immunité à médiation cellulaire. Le liposome peut également induire la présentation d'antigène par une cellule dendritique mature.
Atthachai Homhuan
Harashima Hideyoshi
Kogure Kentaro
Moriguchi Rumiko
Nakamura Takashi
Mcfadden Fincham
National University Corporation Hokkaido University
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