Methods and compositions for radioimmunotherapy of brain and...

Details Methods and compositions for radioimmunotherapy of brain and... Methods and compositions for radioimmunotherapy of brain and...

A - Human Necessities

61

K

A61K 51/10 (2006.01)

Patent

CA 2487692

A method for treating a brain tumor by administering to a patient (i) a multispecific antibody comprising at least one targeting arm that binds to a brain cancer antigen and at least one capture arm that binds to a radionuclide carrier; (ii) a therapeutic radionuclide carrier to which is bound a therapeutic radionuclide, wherein the multispecific antibody, radionuclide carrier and therapeutic radionuclide are administered in a substantially equimolar ratio.

La présente invention concerne une technique de traitement d'une tumeur du cerveau par administration à un patient (i) d'un anticorps multispécifique comprenant au moins un bras de ciblage qui se lie à un antigène de cancer du cerveau et au moins un bras de capture qui se lie à un véhicule de radionucléide, (ii) d'un véhicule de radionucléide thérapeutique auquel est lié un radionucléide thérapeutique, cet anticorps multispécifique, ce véhicule de radionucléide et ce radionucléide étant administrés dans un rapport molaire sensiblement équivalent.

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