Methods for diagnosis and treatment of human diseases...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2382251

Methods for diagnosis and treatment of human disease, particularly human disease characterised by abnormal cytosolic ion composition in diseased cells resulting from reduced or over activity of Na+ transport proteins (e.g. hypertension), are disclosed. Additionally, the specification discloses novel Na+ receptors and isolated DNA molecules encoding same.

L'invention concerne des méthodes de diagnostic et de traitement de maladies humaines, en particulier de maladies humaines caractérisées par une composition ionique cytosolique anormale dans des cellules malades, en raison d'une activité réduite ou d'une hyperactivité des protéines de transport de Na?+¿ (par exemple l'hypertension). De plus, les spécifications concernent également de nouveaux récepteurs de Na?+¿ et des molécules d'ADN isolées codant pour ces derniers.

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