Quinolene derivatives as anti-inflammation agents

Details Quinolene derivatives as anti-inflammation agents Quinolene derivatives as anti-inflammation agents

C - Chemistry, Metallurgy

07

D

C07D 215/36 (2006.01) A61K 31/47 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2418832

The present invention relates to quinoline derivatives of Formula (I), wherein A, R1, R2 and R3 have the value given in the specification. The compounds are useful as inhibitors of COX-II and, therefore, may be used for the treatment of a disease treatable by administration of a selective COX-II inhibitor, such as an inflammatory disease, autoimmune disease.

L'invention concerne des dérivés quinoline correspondant à la formule (I) dans laquelle A, R?1¿, R?2¿ et R?3¿ possèdent les notations données dans la description. Ces composés sont utiles en tant qu'inhibiteurs de COX-II et on peut donc les employer dans le traitement d'une maladie, telle qu'une maladie inflammatoires ou auto-immune, par administration d'un inhibiteur sélectif de COX-II.

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