A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2730048
The invention provides a method for the treatment of a patient having a more severe form of Alzheimer's disease (AD), where the severe form of AD is characterized by pathogenic deposits of amyloid beta peptide (A.beta.), comprising the administration of an immunogenic fragment of A.beta. capable of inducing an immune response in the form of antibodies to specific to the pathogenic deposits of A.beta. and, in particular, to neurotoxic forms of A.beta. including N-terminally truncated forms of A.beta.. The invention further provides a method for selecting a suitable immunogenic fragment of A.beta. for the treatment of a more severe form of AD.
La présente invention concerne un procédé pour le traitement dun patient présentant une forme plus grave de la maladie dAlzheimer (MA), la forme grave de MA étant caractérisée par des dépôts pathogènes du peptide bêta-amyloïde (Aß), consistant en ladministration dun fragment immunogène de Aß pouvant induire une réponse immunitaire sous la forme danticorps dirigés spécifiquement contre les dépôts pathogènes de Aß et, en particulier, contre les formes neurotoxiques de Aß comprenant les formes de Aß tronquées en N-terminal. Linvention concerne en outre un procédé permettant de sélectionner un fragment immunogène de Aß approprié pour le traitement dune forme plus grave de MA.
Citron Michael
Kinney Gene G.
Liang Xiaoping
Rosen Laura B.
Savage Mary J.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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