C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61P 25/04 (2006.01) C07K 1/16 (2006.01)
Patent
CA 2565731
The present invention refers to analog compounds of peptides having the amino acid sequences SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 or SEQ ID NO: 4, including analgesic peptides derived from snakes of species such as Crotalus durissus terrificus ; their uses in the treatment, diagnosis and prevention of painful conditions or mediated by opioid receptors, their pharmaceutical compositions and their methods of preparation and purification, including their uses in the identification of analgesic compounds.
La présente invention concerne des composés analogues de peptides possédant les séquences d'acides aminés SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, y compris de peptides analgésiques dérivés de serpents d'espèces telles que Crotalus durissus terrificus. L'invention concerne également l'utilisation de ces composés pour le traitement, le diagnostic et la prévention de la douleur ou de troubles induits par les récepteurs opioïdes, des compositions pharmaceutiques renfermant ces composés, des procédés destinés à la préparation et à la purification de ces composés, ainsi que l'utilisation de ces composés pour l'identification de composés analgésiques.
Brigatte Patricia
Camargo Antonio
Cury Yara
Giorgi Renata
Gutierrez Vanessa
Cury Yara
Fundacao de Amparo A. Pesquisa Do Estado de Sao Paulo - Fapesp
Laboratorio Biosintetica Ltda.
Moffat & Co.
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