Neuroprotective benzoate and benzamide compounds

Details Neuroprotective benzoate and benzamide compounds Neuroprotective benzoate and benzamide compounds

A - Human Necessities

61

K

A61K 31/135 (2006.01)

Patent

CA 2561452

The invention provides a therapeutic method for treating at least one symptom of a neurological disorder or disease such as Alzheimer~s disease in a mammal, such as a human, wherein the toxicity of a pathogen of .beta. amyloid peptide and/or glutamate in mammalian cells is implicated and inhibition of the subsequently-induced pathological pathways is desired comprising administering to a mammal in need of such therapy, an effective amount of an N-arylamide or an (N-aminoalkyl)benzamide, including pharmaceutically acceptable salts thereof.

L'invention concerne un procédé thérapeutique destiné au traitement d'au moins un symptôme d'un trouble ou d'une maladie neurologique tels que la maladie d'Alzheimer chez un mammifère, tel que l'homme. Dans ce procédé, la toxicité d'un pathogène du .szlig. amyloïde peptide et/ou du glutamate dans les cellules de mammifère est impliquée et l'inhibition des voies pathologiques induites ultérieurement est souhaitée, comportant l'administration chez un mammifère ayant besoin d'un tel traitement d'une quantité efficace d'un N-arylamide ou d'un (N-aminoalkyle)benzamide, y compris de leurs sels pharmaceutiquement tolérables.

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