C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/515 (2006.01)
Patent
CA 2588765
The invention, relates to the use or a fragment or variant thereof to treat diseases or conditions characterised by neuronal injury or death, or axonal degeneration, especially neurodegenerative diseases such as Atmyotrophic Lateral Sclerosis (ALS). The invention also describes a plurality of mutations of the human angiogenin gene which are associated with a neurodegenerative disease phenotype, and. particularly a ALS phenotype, Also described is .a, method; of assessing whether an individual is afflicted with, or generically predisposed to develop, a disease or condition characterised by neuronal injury or death, or axonal degeneration.
Utilisation d'angiogenine, ou son fragment ou variant pour traiter les maladies ou pathologies caractérisées par une lésion ou une mort neuronale, ou une dégénération axonale, notamment des maladies neurodégénératives, telles que la sclérose latérale amyotrophique (ALS). Pluralité de mutations du gène de l'angiogenine humain associées à un phénotype de maladie neurodégénérative, et particulièrement un phénotype ALS. Procédé d'évaluation si un individu est affligé ou prédisposé à développer une maladie ou une pathologie caractérisée par l'adhésion ou la mort neuronale ou la dégénération axonale.
Greenway Matt
Hardiman Orla
Gowling Lafleur Henderson Llp
Royal College Of Surgeons In Ireland
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