A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/30 (2006.01) A61K 9/06 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/14 (2006.01) A61K 47/24 (2006.01)
Patent
CA 2348540
A composition and procedures for its formation and administration are described, which provide for a convenient, efficacious and simple transdermal administration of medications from a topically applied cream. No transmission through a membrane is involved. The composition incorporates at least two separate penetration enhancers which function synergistically to provide for rapid but controllable transport of the medication from the cream into the skin. The use of a plurality of penetration enhancers, at least one of which facilitates the separation of medication from the cream and at least a second of which alters the structure of the outer layers of skin, particularly the stratum corneum, enhances migration of the drug through the stratum corneum.
L'invention concerne une composition et des procédés de réalisation et d'administration de cette composition qui permettent une administration transdermique de médicaments pratique, efficace et simple, à partir d'une crème appliquée localement. Selon ladite invention, il n'y a pas de passage du médicament à travers une membrane. Ladite composition comprend au moins deux agents séparés améliorant la pénétration qui fonctionnent en synergie pour permettre le transport rapide mais maîtrisable du médicament de la crème à l'intérieur de la peau. L'utilisation d'une pluralité d'agents améliorant la pénétration, dont au moins un facilite la séparation du médicament de la crème et dont au moins un second altère la structure des couches extérieures de la peau, en particulier la couche cornée, facilite la migration du médicament à travers ladite couche cornée.
Grasela John C.
Grasela Joseph C.
Jubenville Robert M.
Mccloskey Joseph J.
Grasela John C.
Grasela Joseph C.
Jubenville Robert M.
Mccloskey Joseph J.
Smart & Biggar
LandOfFree
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