Radioimmunotherapy using .alpha.-particles emission

Details Radioimmunotherapy using .alpha.-particles emission Radioimmunotherapy using .alpha.-particles emission

A - Human Necessities

61

K

167/101

A61K 51/10 (2006.01)

Patent

CA 2034484

The present invention relate to the use of Actinium or one of its daughters in radioimmunotherapy. Also provided are immunoconjugates comprising an isotope, a chelating agent and a slowly localizing antibody. The invention also includes pharma ceutical compositions comprising said immunoconjugates, as well as such compositions comprising one or more scavenging agents. The compositions according to the invention are particularly useful for the treatment of micrometastases in adjuvant therapy. as well as for treatment of localized tumors.

L'invention concerne l'emploi d'Actinium ou d'un des éléments de sa filiation en radioimmunothérapie. L'invention concerne également des immunoconjugués comprenant un isotope, un agent de chélation et un anticorps de localisation lente. L'invention concerne en outre des compositions pharmaceutiques comprenant lesdits immunoconjugués, ainsi que de telles compositions comprenant un ou plusieurs agents d'épuration. Les compositions de l'invention sont particulièrement utiles dans le traitement de micrométastases en thérapie auxiliaire, ainsi que dans le traitement de tumeurs localisées.

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