Tyrosine phosphorylation in protozoans

Details Tyrosine phosphorylation in protozoans Tyrosine phosphorylation in protozoans

A - Human Necessities

61

K

A61K 33/24 (2006.01) A61K 31/275 (2006.01) A61K 31/35 (2006.01) A61K 33/00 (2006.01)

Patent

CA 2064550

ABSTRACT OF THE DISCLOSURE A method for the treatment of microbial-induced disorders such as the protozoa- based diseases malaria and leishmania is described in which the phosphorylation of tyrosine residues in proteins is modulated. Specific phosphorylation of trypanosomal proteins, in T.brucei, is disclosed. Tyrosine kinase and tyrosine phosphatase inhibitors are disclosed for administration to patients in the treatment method of the described invention.

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