Oligodendrocyte production from multipotent neural stem cells

Details Oligodendrocyte production from multipotent neural stem cells Oligodendrocyte production from multipotent neural stem cells

C - Chemistry, Metallurgy

12

N

C12N 5/079 (2010.01) A61K 35/30 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61P 25/00 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2492542

This invention relates to methods of producing oligodendrocytes from multipotent neural stem cells by using at least one oligodendrocyte promoting factor, particularly granulocyte-macrophage colony stimulating factor, granulocyte colony stimulating factor, interleukin 3 or interleukin 5. The neural stem cells may optionally be expanded prior to being subjected to the oligodendrocyte promoting factor.

L'invention concerne des procédés de production d'oligodendrocytes à partir de cellules souches neurales multipotentes au moyen d'au moins un facteur de promotion d'oligodendrocyte, en particulier du facteur de stimulation de colonie de granulocyte-macrophage, d'un facteur de stimulation de colonie de granulocyte, d'interleukine 3 ou d'interleukine 5. Les cellules souches neurales peuvent éventuellement subir un développement avant d'être soumises au facteur de promotion d'oligodendrocyte.

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