Polymer matrix/cell construct for bladder reconstruction

Details Polymer matrix/cell construct for bladder reconstruction Polymer matrix/cell construct for bladder reconstruction

A - Human Necessities

61

L

A61L 27/38 (2006.01) A61F 2/04 (2006.01) A61L 27/14 (2006.01) A61L 27/18 (2006.01) A61L 27/58 (2006.01)

Patent

CA 2307567

The invention is directed to methods and devices for the reconstruction, repair, augmentation or replacement of laminarily organized luminal organs or tissue structures in a patient in need of such treatment. The device comprises a biocompatible synthetic or natural polymeric matrix shaped to conform to at least a part of the luminal organ or tissue structure with a first cell population on or in a first area and a second cell population such as a smooth muscle cell population in a second area of the polymeric matrix. The method involves grafting the device to an area in a patient in need of treatment. The polymeric matrix comprises a biocompatible and biodegradable material.

Cette invention concerne des procédés et des dispositifs qui permettent de reconstruire, de réparer, d'augmenter ou de remplacer des structures tissulaires ou des organes luminaux disposés de manière stratifiée chez des patients devant subir un tel traitement. Ce dispositif comprend une matrice polymère synthétique ou naturelle bio-compatible dont la forme s'adapte à une partie au moins de la structure tissulaire ou de l'organe luminal. La matrice polymère comprend une première population de cellules qui se trouve sur ou dans une première zone, ainsi qu'une seconde population de cellules, telle qu'une population de cellules des muscles mous, qui se dans une seconde zone. Ce procédé consiste à greffer ce dispositif dans la zone qui doit être traitée chez un patient. Cette matrice polymère comprend un matériau bio-compatible et biodégradable.

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