Sulfoxide and bis-sulfoxide compounds and compositions for...

C - Chemistry – Metallurgy – 07 – C

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C07C 317/18 (2006.01) A61K 31/10 (2006.01) A61P 9/00 (2006.01) C07C 317/04 (2006.01) C07C 317/10 (2006.01) C07C 317/14 (2006.01) C07C 317/22 (2006.01) C07C 317/24 (2006.01) C07C 317/44 (2006.01) C07D 233/40 (2006.01) C07D 233/42 (2006.01) C07D 249/04 (2006.01) C07D 257/04 (2006.01) C07D 261/12 (2006.01) C07D 305/12 (2006.01) C07D 307/32 (2006.01) C07D 309/12 (2006.01) C07D 309/30 (2006.01) C07D 309/40 (2006.01) C07D 333/48 (2006.01) C07D 335/02 (2006.01) C07D 495/04 (2006.01) C07F 9/09 (2006.01) C07F 9/24 (

Patent

CA 2425678

The present invention relates to novel sulfoxide and bis-sulfoxide compounds, compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing caridovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor- related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

L'invention concerne de nouveaux composés de sulfoxyde et de bis-sulfoxyde, des compositions contenant des composés de sulfoxyde et de bis-sulfoxyde, ainsi que des procédés utiles dans le traitement et la prévention de maladies cardio-vasculaires, de dyslipidémies, de dysprotéinémies et de troubles du métabolisme du glucose, qui consistent à administrer une composition renfermant un composé d'éther. Les composés, compositions et procédés de l'invention sont aussi utiles pour traiter et prévenir la maladie d'Alzheimer, le syndrome X, des troubles associés aux récepteurs activés par les proliférateurs des peroxisomes, la septicémie, les affections thrombotiques, l'obésité, la pancréatite, l'hypertension, la néphropathie, l'inflammation cancéreuse et l'impotence. Dans certaines formes de réalisation, ces composés, compositions et procédés sont utiles en combinaison avec d'autres traitements, p. ex. hypocholestérolémiants et hypoglycémiants.

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