C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/505 (2006.01) C07D 209/04 (2006.01) C07D 209/08 (2006.01) C07D 209/30 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2405607
This invention relates to indole derivatives of the general formula (I) wherein R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkylsulfonyl, cycloalkylsulfonyl, cycloalkylalkylsulfonyl, dialkylsulfamoyl, N-cycloalkyl-N-alkylsulfamoyl, heterocyclylalkyl or phenylalkyl; R2 is hydrogen, halogen, alkyl, alkanoyl, phenyl, phenylalkyl or heterocyclylalkyl; R3 is hydrogen, alkyl; and R4 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkylsulfonyl, cycloalkylsulfonyl, cycloalkylalkylsulfonyl, dialkylsulfamoyl, N-cycloalkyl-N-alkylsulfamoyl, heterocyclylalkyl, or phenylalkyl; and pharmaceutically acceptable acid addition salts of these compounds, there use as therapeutically active substances; medicaments based on these substances, optionally in combination with sulphonamides, and their production; the use of these substances as medicaments and for the production of antibacterially-active medicaments; as well as the manufacture of the compounds of formula (I) and their pharmaceutically acceptable acid addition salts and intermediates for their manufacture.
La présente invention concerne des dérivés d'indole répondant à la formule générale (1) dans laquelle R?1¿ représente un alkyle, alcényle, alkynyle, cycloalkyle, cycloalkylalkyle, alkylsulfonyle, cycloalkylsulfonyle, cycloalkylalkylsulfonyle, dialkylsulfamoyle, N-cycloalkyl-N-alkylsulfamoyle, hétérocyclylalkyle ou phénylylalkyle; R?2¿ représente un hydrogène, halogène, alkyle, alkanoyle, phényle, phénylalkyle, ou hétérocyclylalkyle; R?3¿ représente un hydrogène, alkyle; et R?4¿ représente un alkyle, alcényle, alkynyle, cycloalkyle, cycloalkylalkyle, alkylsulfonyle, cycloalkylkylsulfonyle, cycloalkylalkylsulfamoyle, dialkylsulfamoyle, N-cycloalkyl-N-alkylsulfamoyle, hétérocyclylalkyle, ou phénylalkyle; et des sels d'addition acide pharmaceutiquement acceptables de ces composés, leur utilisation comme substances thérapeutiques actives ; des médicaments à base de ces substances, facultativement combinés avec des sulfamides, et leur production ; l'utilisation de ces substances comme médicaments et dans la production de médicaments à activité antibactérienne ; ainsi que la fabrication des composés de la formule (1) et de leurs sels d'addition acide pharmaceutiquement acceptables et leurs intermédiaires de fabrication.
Mattei Patrizio
Pflieger Philippe
Basilea Pharmaceutica Ag
Borden Ladner Gervais Llp
LandOfFree
Pyrimidinyl methyl indole derivatives with antibacterial... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyrimidinyl methyl indole derivatives with antibacterial..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrimidinyl methyl indole derivatives with antibacterial... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1702878