Oxazole and thiazole combinatorial libraries

Details Oxazole and thiazole combinatorial libraries Oxazole and thiazole combinatorial libraries

C - Chemistry, Metallurgy

07

D

C07D 277/04 (2006.01) C07B 61/00 (2006.01) C07D 263/30 (2006.01) C07D 263/34 (2006.01) C07D 275/02 (2006.01) C07D 277/08 (2006.01) C07D 277/20 (2006.01) C07D 277/22 (2006.01) C07D 277/28 (2006.01) C07D 277/30 (2006.01) C07D 277/56 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2368026

This invention provides a novel method for synthesizing an ensemble of peptides that allows for the generation of an unlimited number of antibiotic compounds. More specifically, the method comprises utilizes synthetic heterocyclic amino acides containing thaizole and/or oxazole as building blocks in a solid phase combinatorial synthesis to yield natural and unnatural antibiotic compounds.

La présente invention concerne un procédé de synthèse d'un ensemble de peptides permettant la génération d'un nombre illimité de composés antibiotiques. Le procédé consiste, plus spécifiquement, à utiliser des acides aminés hétérocycliques synthétiques contenant de l'oxazole et/ou du thiazole comme motifs de structure en synthèse combinatoire en phase solide afin d'obtenir des composés antibiotiques naturels et artificiels.

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