Fas ligand fusion protein

Details Fas ligand fusion protein Fas ligand fusion protein

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) C07K 1/107 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2232876

A protein comprising the human Fas Ligand protein (hFasL) or a truncated human Fas Ligand protein or a functionally equivalent variant thereof that retain the Fas receptor-binding and apoptosis-inducing properties of hFasL and, linked either directly or indirectly to its C-terminus, a glycophospholipid is useful in preventing or treating tissue or organ graft rejection.

Cette protéine comprend, d'une part, la protéine ligand humaine Fas ou une protéine ligand humaine Fas tronquée ou une variante de celle-ci, fonctionnellement équivalente, retenant les propriétés de hFasL, lesquelles consistent à fixer le récepteur de Fas et à induire l'apoptose, et liée soit directement soit indirectement à sa partie C-terminale, et d'autre part, un glycophospholipide. Cette protéine est utile pour prévenir ou traiter le rejet de greffe d'organe ou de tissu.

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