Methods of identification of biomarkers with mass...

Details Methods of identification of biomarkers with mass... Methods of identification of biomarkers with mass...

G - Physics

01

N

G01N 24/00 (2006.01)

Patent

CA 2596518

The present invention provides methods for identifying various biological states. Methods for diagnosis of diseases, in particular cardiovascular and brain diseases, are provided herein. One aspect of the invention is the analysis of lipoprotein complexes with summary survey scan mass spectrum for the analysis of biological states. Another aspect of the invention is the use of matrix assisted laser desorption ionization (MALDI) mass spectrometer to analysis lipoprotein complexes for the diagnosis of cardiovascular and brain diseases. Yet another aspect of the invention is a method of diagnosis of brain diseases by evaluating the characteristics of lipoprotein complexes.

L'invention concerne des procédés d'identification de différents états biologiques et des procédés de diagnostic de maladies, notamment de maladies cardio-vasculaires et cérébrales. Selon une variante, on prévoit l'analyse de complexes de lipoprotéines au moyen d'un spectre de masse par balayage d'ensemble pour l'analyse d'états biologiques. Selon une autre variante, on utilise un spectromètre de masse à désorption/ionisation laser assistée par matrice (MALDI) pour analyser les complexes de lipoprotéines en vue du diagnostic de maladies cardio-vasculaires et cérébrales. Selon une autre variante encore, on prévoit une méthode de diagnostic de maladies cérébrales par évaluation des caractéristiques des complexes de lipoprotéines.

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